Discrimination and the Voting Rights Act of 1965 Essay

The South was racially biased for years after the Civil War. The Southern states would create legislation to enact â€Å"Jim Crow† laws upon the black community. Segregation was at its peak in the United States and the black community had been oppressed long enough. Conforming to the segregated South only caused hostility. The government that recognized blacks as members of society ignored them. In fact, the government that could protect the black community from the violence incurred by terrorist groups was often members of the groups themselves. Rebellion was the only and final option. In order for the Voting Rights Act of 1965 to be ratified by Congress, the black community needed to rebel against the â€Å"Jim Crow† laws of the South, the violence invoked by hate organizations, as well as (with assistance from white college students) the hypocrisies of the United States government. Jim Crow became a general term used in the South to refer to the segregation and discrimination laws that affected African-American life. The name originated from â€Å"an 1832 song called Jump Jim Crow by Thomas Rice† (Hillstrom 9). The song may have been named after a slave that Rice knew or from the expression â€Å"black as a crow†. The main purpose of Jim Crow laws was to segregate and disenfranchise the black community. During the Jim Crow era, â€Å"various states passed laws that banned blacks from hospitals, schools, parks, theaters, and restaurants† (Hillstrom 9). In all cases, the facilities marked colored  were noticeably inferior to the whites. Many cities and states would ratify their own specific Jim Crow laws. Some laws such as blacks having to cross the street when a white woman, on the same sidewalk, was walking toward them or â€Å"maintaining a separate building, on separate ground, for the admission, care, instruction, and support of all blind persons of colored or black race† (Bell 4) were absurd. In the summer of 1955, a 14-year-old boy was brutally beaten and killed for allegedly whistling at a white woman. The husband and brother-in-law of the woman were charged with murder but were acquitted of all charges after only sixty minutes of deliberation. In an interview months later, with protection from the Constitutional clause of double jeopardy, both brothers openly admitted, without remorse, to maiming and killing the boy. The quick deliberation and acquittal outraged the country and helped to energize the Civil Rights Movement. The Jim Crow laws were progressively getting worse for the black community. Lawmakers needed to be black, or abolitionists, in order for the laws to change. Rebellion by way of the ballot box was the answer. In The United States, the democratic process is supposed to allow voters a chance to correct social injustices. Citizens within the black community should have the ability to vote black candidates into office. Blacks could elect city council members, mayors, judges, and even state representatives. But in Mississippi the people in power, all of whom were white, denied blacks the opportunity to vote. The white community believed that if blacks achieved the right to vote, they would make up the majority. The black majority would force out the racist whites from power and change the social injustices. Mississippi Senator Eugene Bilbo stated, â€Å"If you let a few (blacks) register to vote this year, next year there will be twice as many, and the first thing you know, the whole thing will be out of hand† (Aretha 20). The black community needed to vote in order to achieve change. Without the right to vote, segregation and the disenfranchisement of African-Americans would cease to change. The southern-white lawmakers created a complicated system to keep African-Americans from voting. â€Å"White local and state officials systematically kept blacks from voting through formal methods, such as poll taxes and literacy tests† (Summer 1964). The literacy test prevented even educated African-Americans from achieving voter registration. The test required voters to â€Å"read and interpret a section of the state constitution to the â€Å"satisfactory† of the registrar† (Aretha 21). This allowed â€Å"white registrars to decide whether or not a person passed. Most blacks, even those with doctoral degrees, failed† (Cozzens 1). Fear was a constant tactic for the racist south. Black applicants â€Å"had to give, under oath, information about his or her address, employment, and family members. This information would then be given to the applicants employer, the KKK, and other organizations† (Let Freedom Ring 149). Having the bravery to rebel against society, by registering to vote, caused many blacks to fear retaliation from the KKK and their employer. In the post-Civil War era many white Southerners resented the changes imposed by the Union. In the years during Reconstruction, terrorist groups sprang up all over the south. The Ku Klux Klan (KKK) and the White Citizens Council, â€Å"the uptown Klan†, which was often made up of sheriffs, doctors, lawyers, and even mayors, quickly gain thousands of members across the south. The KKK had four explicit tactics in their war against blacks, â€Å"First was cross burning, second would be the burning and dynamiting of houses and buildings, third was flogging, and the Fourth was extermination† (Watson 143). In 1964, a single Mississippian county had â€Å"37 churches and 30 black homes and businesses were firebombed or burned, and the cases often went unsolved† (Summer 1964). Hate crimes were becoming increasingly common and extremely brutal throughout the South. The black community needed and sought change. After many years of brutality and hatred, many blacks believed they were inferior to whites. To combat the inferiority thought, Bob Moses created â€Å"Freedom Schools† and community centers open to the black community. â€Å"The community centers would offer facilities limited by the Jim Crow system: libraries, arts and crafts, daycare, and literacy classes† (Burner 124). Freedom Schools taught students African-American history and current events. Moses saw the Freedom Schools â€Å"as an opportunity to teach the â€Å"politics of Mississippi† and begin to build a core of educated leadership in the state† (Burner 124). Members of SNCC and CORE believed that rebellion was a necessity, and rebelling with nonviolent methods would allow the nation to see the atrocities inflicted in the south. In order to gain momentum, the black community needed assistance from the federal government and the national media. The Student Nonviolent Coordinating Committee (SNCC) came to the forefront for reform. In 1961, seven blacks and six whites tested the federal law, which called for the desegregation on interstate travel. Called the Freedom Riders, thirteen people â€Å"rode buses into the south, daring the federal government to enforce the law. The Freedom Riders were arrested in North Carolina, beaten by mobs in South Carolina, and saw their buses fire bombed in Alabama† (Watson 24). The thirteen men rode into the south with whites sitting in the back of the bus, the blacks in the front, and would use the same facilities at bus stations as stated by federal law. James Farmer, one of the thirteen riders and the director of CORE (Congress of Racial Equality) stated, â€Å"We felt we could count on the racists of the South to create a crisis so that the federal government would be compelled to enforce the law† (Cozzens 1). The rebellion of the thirteen brave men to ride into the south created the national media attention the activist desperately needed. The national media started to show the country how hypocritical the United States had become. Men of many races fought for their country in a time of war, but came home to a country that was at war within itself. In the early 1960’s, the black community rebelling for equal rights began to capture the attention of Americans across the country. 1964, a presidential election year, was a pivotal time to rebel for the African-American right to vote. For generations the south held a dominant Democratic Party. Rebelling against the injustices set by the â€Å"whites-only† Democratic Party could only be changed by use of the ballot box. Bob Moses, a member of SNCC, decided to send volunteers into Mississippi to register voters. The voter registration drive came to be known as â€Å"Freedom Summer†. Bob Moses outlined the goals of Freedom Summer as to increase black voter registration and to organize a legally constituted â€Å"Freedom Democratic Party† to compete with the whites-only Democratic Party. Moses instructed recruits, â€Å"Don’t come to Mississippi this summer to save the Mississippi Negro. Only come if you understand, really understand, that his freedom and yours are one† (Aretha 41). To achieve the attention of the national media, Moses and other members of SNCC decided to recruit white college students from the north. â€Å"Violence against Northern Whites would at least get Mississippi on the nightly news† (Rachall 173). Children of the dominant social class, rebelling against their parents and the accepted society of the south, in fact attracted national attention. Moses stated, â€Å"These students bring the rest of the country with them. They are from good schools and their parents are influential. The interest of the country is awakened and when that happens, the government responds† (Aretha 30). Rebelling against the hypocrisies of their nation, their parents, and even society, white college students came by the hundreds to volunteer for â€Å"Freedom Summer†. Volunteers went to Oxford, Ohio, currently the campus of Miami University, for a weeklong orientation. Volunteers were not going to be paid and would need to support themselves. They were told to bring money for living expenses, bail, and even medical bills if necessary. The volunteers had to be prepared for death. James Forman, of SNCC, told the volunteers, â€Å"I may be killed, you may be killed, the whole staff may be killed† (Cozzens 3). The students were told that if arrested, go to jail quietly. The authorities would have cause to react violently if volunteers were to resist. The national media and the south would exploit the aggression and discredit the actions of a nonaggressive rebellion. Rebellious college students used Hitler and Mussolini’s ideologies, fascism and the idea of a united master race, as a direct correlation to what was happening to blacks in the South. World War II was only twenty years prior and the Cold War was just beginning. Many Americans still held hostility towards Germany and the idea of racial class distinctions. The spread of communism and Nuclear War were constant backdrops to every evening newscast. If the United States could announce to the world their â€Å"Policy of Containment† then the world should hear about hypocrisy within the United States. The Blacks and volunteers used the memories of the war to prove how fascist ideas were being entertained. Rebelling and protesting would allow the world to see the deceitful ways America. In June 1964 rebellion against hate crimes, voter rights, and the segregation of blacks was underway. A Michigan State student said of their arrival in Mississippi, â€Å"The greyhound bus dropped us off on a residential street, we had no idea where we were. Almost immediately we found ourselves being circled by pickup trucks with rifles and big dogs in the back† (Aretha 47). Jane Adams, Southern Illinois University, stated, â€Å"Mississippi had geared up for war. They saw us as invaders coming in for a complete assault on their way of life. Everybody on both sides expected that there would be a bloodbath. We all expected we could die† (Aretha 47). Two white men and a black man rebelling against southern society were easy targets for police. Two white men, Michael Schwerner and Andrew Goodman, as well as a black volunteer James Chaney were last seen going to a bombed out church to offer their condolences to the congregation and to offer their assistance with the investigation. The men disappeared after being singled out by the racist authorities. The next day, staff called police when the three men failed to check in at their headquarters. The police, often members of the KKK, often used their authority to invoke fear into both black and white volunteers. KKK pamphlets declared, â€Å"We are now in the midst of the long, hot summer of agitation which was promised to the Innocent People of Mississippi by the savage blacks and their communist masters† (Watson 142). After the disappearance of Schwerner, Goodman, and Chaney, President Johnson and the FBI became involved. The story of the missing, as well as the peaceful rebellion, quickly gained national attention. Two of the men’s skin color became a key factor for the instant media. Rita Shwerner declared, â€Å"We all know that the search with hundreds of sailors is because my husband and Goodman are white. If only Chaney was involved, nothing would have been done† (Rachal 168). The media may have not paid much attention if only a black man went missing. The media told the story of the missing men on nationally televised nightly newscasts and public outcry immediately followed. Finally the south received assistance from the federal government. Lyndon Johnson sent hundreds of men from the military to search for the three men. As the search went on, the Mississippi Governor and a member of the White Citizens Council exclaimed, â€Å"Of course I don’t approve of murder, but those kids were asking for trouble† (Aretha 50). The shot and beaten bodies of the missing men were found after a month. It later surfaced that the local police arrested the three men for speeding. After dark, the police released the men to the KKK. Eighteen men were originally arrested but only a few were convicted and served light sentences. Finally in 2005, 41 years after the murders, Edgar Ray Killen was convicted of manslaughter and sentenced to three life sentences, without the possibility of parole, to be served in succession. After the deaths of Schwerner, Goodman, and Chaney was the perfect time for blacks to rebel louder. To achieve the voting rights for the segregated community, the rebellious blacks and whites created a stronger alliance than ever before. By coming together, the black community showed America that the rebellion would not end until equal rights and the ability to vote was achieved. The summer of 1964 became the high water mark for equal rights in America. â€Å"Freedom Summer† along with nonviolent protests across the south lead to the signing of Section 2 of the Voting Rights Act of 1965. The Voting Rights Act â€Å"prohibits voting practices or procedures that discriminate on the basis of race, color. Discrimination to voting applies nationwide to any voting standard, practice, or procedure that results in the denial of the right of any citizen to vote. Section 2 is permanent and has no expiration date† (Section 2). Rebellion was a necessity to end the disenfranchisement of the African-American community. Rebellion for the black community was not to conform to the racist south, but to consciously do the opposite. Without rebellion and bravery the south may have never changed. Volunteer Bruce Hartford professed, â€Å"We used to say: If you don’t like the history they’re teaching you in school, go out and make some of your own† (Aretha 35).

Tackling Health Inequalities Teenage Pregnancy Health And Social Care Essay

Socio-economic inequalities in wellness have moved up the policy docket and instead than one attack in undertaking adolescent gestation. These attacks can be understood by guaranting an betterment to the wellness of the poorest of the hapless 1s, through contracting the spreads between those in the hapless society and the rich 1s that are to make good, to turn toing the association between socio-economic place and wellness across the population ( Graham, 2004 ) . Public wellness policy in older industrial states is in a procedure of alteration. A narrow concern with advancing population wellness is giving manner to a broader vision of the ends of policy. The broader vision combines a focal point on wellness addition with a committedness to cut downing inequalities in its societal distribution. This committedness is the basis of the United Kingdom new public wellness policies because England ‘s new scheme seeks ‘an betterment to the wellness of the lowest category in society and besides narrow the spread. ‘Tackling wellness inequalities ‘ is a nucleus driver of policy ( Secretary of State, 1999 ) . Development in the UK is in measure with that elsewhere in Europe. Here, the ends of public wellness policy have been redefined to give greater accent ( Gadikou E. E, Murray C. J and Frenk J, 2000 ; Chang W. C, 2002 ) to undertaking systematic differences in the wellness of advantaged and disadvantaged of us that are sick, and some of us that are non. In so many surveies about undertaking wellness inequalities ( Braveman A, Krieger N and Lynch J, 2000 ; Marmot M, 2001 ) , it has been said that wellness inequalities are more widely understood to mention, non to fluctuations between persons, but no differences between societal groups. In most states, including the UK, wellness inequalities are shorthand for socio-economic inequalities in wellness, whether measured at the person or are flat. Health inequalities which relate to other constructions of inequality like gender or ethnicity are typically labeled in these footings as gender inequalities in wellness, cultural inequalities in wellness etc. to undertake wellness inequalities is hence to undertake unfairness ( Milburn A, 2001 ) . To undertake wellness inequalities in teenage gestation, so good wellness is the manner frontward to every person and non merely a peculiar group or set of people. Decreasing wellness disadvantages, contracting wellness spreads and diminishing wellness gradients can be used to undertake wellness inequalities ( Graham, 2004 ) Undertaking Health Inequalities: There has been a really big sum of research on the causes of wellness inequalities in the universe but less grounds on how to cut down, tackle or convey it to a halt. The major purpose of undertaking wellness inequalities is to construct a more equal distribution of wellness between the societal groups so that every single gets to benefits. Health inequalities were known in the UK after the Black Report was published. The Black Report showed that there had been an betterment in wellness across societal categories with the aid of National Health Scheme ( NHS ) . It is clear that the simplest manner to undertake wellness inequalities is to better on the societal determiners of wellness in which the World Health Organization ( WHO ) defined the societal determiners of wellness as ‘the status in which people are born, turn, adapt, work and age including the wellness system. The figure below shows a sum-up of these conditions as proposed by Dahlgren and Whitehead ( 1991 ) . Figure 1 Dahlgren G. and Whitehead M. ( 1991 ) In UK in the twelvemonth 1980 when the Black Report was foremost produced on the issues of wellness inequalities. Sir Michael Marmot who is an epidemiologist at University College London, published an article on the relationship between wellness and poorness on the Fair Society, Healthy Lives. He described his article Fair Society as a societal gradient in wellness. Michael Marmot said that the causes of wellness inequalities includes life styles such as smoking which remains more common, drug maltreatment, fleshiness, is increasing fastest, adolescent gestation, amongst the hapless in England on the survey The Economist. Tackling wellness inequalities is described as a committedness ‘to break the nexus between poorness and sick wellness ‘ and ‘also improve the wellness of the lowest category ‘ ( Millburn A, 2001 ) . Reducing Health Disadvantages: At one terminal of the continuum, wellness inequality describes the hapless wellness of hapless groups and communities. Hansard ( 1998 ) said wellness inequality is the nexus between poorness and sick wellness. In this position, wellness inequality is a construct which captures the wellness effects of poorness. Health inequalities are the wellness disadvantages which result from societal disadvantage. It is an apprehension of wellness inequalities which is in line with the authorities ‘s committedness end ‘to make wellness better to the hapless ‘ . It is an of import policy end in which hapless groups and hapless communities endures rates of morbidity and mortality which the remainder of the population has left behind ( Townsend and Davidson, 1982 ; ONS, 2001 ) . There is a powerful moral statement for undertaking these absolute wellness disadvantages. It is an statement which asserts that wellness is a basic demand which no 1 should be unnecessarily denied. It is ‘a really simple freedom, the ability to last instead than yield to premature mortality ‘ . It is a moral place which puts the wellness of the ( planetary ) hapless at the top of the policy docket. World Health Organisation ( WHO, 1999 ) reported that ‘first and first, there is a demand to cut down greatly the load of extra mortality and morbidity suffered by the hapless ‘ . In a state every bit rich as the UK, there are few who would non see the hapless wellness of hapless communities as compromising the simple freedom to last. Average criterions of wellness achieved two decennaries ago should be accomplishable by the poorest now. Specifying wellness inequalities as wellness disadvantages aligns public wellness policy with other elements of the authorities ‘s public assistance programme. It provides a span between the public wellness and societal exclusion docket, maneuvering both towards intercessions targeted at groups vulnerable to societal disadvantage. However, while offering policy advantages, specifying wellness inequalities as wellness a disadvantage is non without its jobs. It turns socio-economic inequality from a construction which impacts on all to a status to which merely those at the underside are exposed. It is the lowest socio-economic groups and the poorest communities who are ‘suffer the result ‘ , ‘health inequalities which is the life style of the people and from low income, hapless instruction, bad lodging, poorness, pollution, low educational criterions, and joblessness ‘ ( DoH, 1998 ) . First, undertaking wellness inequality is non a population broad scheme but it is one confined to sub-groups which make up a comparatively little proportion of the population. Second, undertaking wellness inequality does non widen to conveying degrees of wellness in the poorest groups closer to the national norm. In a society where overall rates of wellness are bettering, absolute betterments in their wellness possibly sufficient to contract the spread between the worst and better away. As a consequence, better wellness among the poorest group has been associated with a widening spread in life anticipation between the underside and the top. Narrowing Health Gaps: At the mid-point on the continuum is a place which focuses non merely on the hapless wellness of hapless groups but besides on their wellness relation to other groups. Here, wellness inequalities are defined in footings of wellness spreads. The Chief Medical Officer ( CMO England, 2001 ) refers to wellness inequality in footings of ‘the spread in wellness between the best off and the worst off in the society ‘ . The marks for undertaking wellness inequalities, nevertheless, follow a different preparation of the wellness spread in footings of the wellness derived functions ( DoH, 2001 ) those in the poorest fortunes and the norm for the population. The wellness spread is a step of wellness inequality widely used in research to compare the wellness of those at the utmost terminals of the socio-economic hierarchy. This construct of wellness inequality is an of import driver for policy which draws attending to the fact that population norms mask broad differences in wellness between societal groups. The moral instance for turn toing wellness spreads is enshrined in the fundamental law of the World Health Organisation ( WHO ) . It suggests that, in any given society, those in the best wellness set a criterion which all should be able to bask. If this is so, it is those in the poorest groups who face the most profound denial of their cardinal human right. This has been an of import focal point of equity-oriented public wellness schemes and in England, wellness inequality marks are wellness spreads marks ( Botting, 2007 ) . Narrowing wellness spreads therefore represents a more ambitious end than rectifying wellness disadvantages. This measure/concept of wellness inequality is an of import driver for policy devising which magnets attending to the fact that the society norms mask broad differences in wellness between groups. As the national norm improves, contracting spreads requires particular attempts to guarantee that figures ( DoH, 2002 ) are non merely maintaining up, but shuting the inequality spread. Reducing wellness gradients~ To foster the continuum, wellness inequalities as an issue in the UK and other European states is non merely about the differences in wellness between the good, the bad and the ugly but alternatively, the relationship between socio-economic place and wellness in a systematic manner. Reduction in wellness gradients have endured across epidemiological periods, cogent evidence in the nineteenth century where infectious/communicable diseases were truly the major cause of decease but now, chronic or Cardio-Vascular disease ( CVD ) diseases has come to remain to take over. Health inequalities follow a societal gradient and to undertake this socio-economic gradient in wellness is truly a challenging policy ( DoH, 2002 ) . The moral instance for undertaking socio-economic gradients lies in the moral equality of people with regard to wellness and merely as World Health Organization fundamental law provinces, the highest come-at-able criterions of wellness ( WHO, 1948 ) should favor everybody regardless the coloring material, race, faith, belief, socio and economic conditions and this rule has long guided Public wellness in England. A socio-economic derived function has a focal point compared to societal disadvantages which widens the frame of wellness inequality policy in three ways: The research for what causes wellness inequality in the society in a systematic difference in life opportunities, the sort of life styles they live and living criterions with people ‘s unequal places in the socio-economic hierarchy Undertaking wellness inequalities becomes a population-wide end to bettering wellness which involves everybody. Reducing wellness gradients provides a comprehensive end to one that subsumes rectifying disadvantages and contracting wellness spreads within the broader end across socio-economic groups. Decrease in socio-economic gradient in teenage gestation, there should be an improve at a faster rate to wellness in other socio-economic groups and policies to rectify wellness disadvantages, shuting the wellness spreads and cut down wellness gradients need to be pursued in tandem. Decision The narrative of wellness inequality is clear because the poorer you are, the more likely you are to be sick and to decease younger. The recent rise in adolescent gestation rates calls for pressing action to cut down or halt the rise and besides originate a lessening in these rates. To efficaciously undertake teenage gestation, wellness inequalities related to teenage gestation demand to be tackled ; the root cause of these inequalities need to be tackled. Health inequalities affect everyone and are evitable ( Woodward & A ; kawachi, 2000 ) . Health inequalities are besides progressively been seen as an unfairness ( Graham, 2004 ) . In other words, good wellness is the right of every person and non merely for a peculiar group or groups of people. These constructs which can be used to undertake wellness inequalities can be complementary instead than reciprocally sole.

The Birth of the American Nation

The American Revolution was not only a battle against the British; it was also a period of transition from a colony to a newly-formed country. Belonging to country that was just liberated from colonial rule, the Americans attempted to apply revolutionary ideology to the building of their nation and the making of their society.They managed to do so by first basing the Declaration of Independence on political freedom, social tolerance and economic opportunity. (http://www. megaessays. com, n. d.) Political freedom played a huge influence on the ideas and ambitions of the revolutionaries and also resulted in social tolerance and economic opportunity. (http://www. megaessays. com, n. d. )Hence, the Declaration of Independence was not a promise or an excuse to wage war with Britain – it was a challenge to the Americans to preserve their sovereignty and develop as a nation. (http://www. megaessays. com, n. d. ) Political freedom for the 13 colonies meant â€Å"breaking away from En gland and being able to develop a sense of identity and a sense of self-government.† (http://megaessays. com, n. d. ) â€Å"Sense of identity and a sense of self-government† referred to a central government that they themselves elected and in whose affairs they have a say. (http://megaessays. com, n. d. ) Indeed, the lack of political representation angered the Americans more than any other atrocity committed against them by the British. (http://megaessays. com, n. d. ) The absence of their opinion in government policy-making allowed the British to enact unjust laws, such as the Sugar Act (1764) and the Stamp Act (1765).The Sugar Act imposed a three-cent tax on imported refined sugar and increased taxes on coffee, indigo and certain types of wine. (http://www. socialstudiesforkids. com, n. d. ) Meanwhile, the Stamp Act required taxation for every printed paper that American colonists used. (http://www. socialstudiesforkids. com, n. d. ) With the 13 colonies free from th e grasp of the British government, the Americans then proceeded to create laws that promoted economic and social liberty. On March 1, 1784, Thomas Jefferson proposed a prohibition on slavery in the entire United States after 1800 (this was narrowly defeated).(http://www. historyplace. com, n. d. ) On May 8, 1785, the US Congress passed the Land Ordinance of 1785, which divided the northwest territories into â€Å"townships set at 6 square miles, subdivided into 36 lots of 640 acres each, with each lot selling for no less than $640. † (http://www. historyplace. com, n. d. ) Thomas Jefferson's Ordinance of Religious Freedom (1786) dictated that â€Å"no man may be forced to attend or support any church or be discriminated against because of his religious preference. † (http://www. historyplace. com, n. d.) The first amendment to the US Constitution was later patterned after this regulation. (http://www. historyplace. com, n. d. ) Despite their nation's independence, the Americans continued using some long-held conventions, laws and customs. For instance, the US Constitution espoused the national government's division into three branches: the legislative, the executive and the judiciary. The legislative branch creates the laws, the executive enforces the laws and the judicial branch interprets the laws. The colonial government has a similar structure. The governor headed the executive branch in each colony.He was â€Å"appointed by the king in the royal colonies, named by the proprietor in the proprietary colonies, and chosen by the voters in the charter colonies. † (www. grazian-archive. com, n. d. ) The governor was assisted by a council (appointed by the same agent that appointed the governor) in administering to the affairs of the colony. The governor (in the royal and proprietary colonies) can also exercise a suspensive (temporary) or full veto upon the colonial legislatures. The legislative branch in the colonial government was a bicame ral unit that was tasked to enact laws.It also had the authority to appoint several administrative officials, starting with the colonial treasurer. (www. grazian-archive. com, n. d) The judicial branch of the colonial government dealt with all cases in the colonies. Colonial judges were either appointed by the king or elected by the people, depending on the type of colony. They were tasked to provide colonists judicial rights that the British people enjoyed at home. (www. grazian-archive. com, n. d) Another long-held convention that the Americans used was the development of individual military institutions for each state.(http://www. americanrevolution. com, n. d. ) This ran parallel to Britain, which had separate military units for the colonies and the mother country. (http://www. americanrevolution. com, n. d. ) A civil war broke out in Britain in 1642, resulting in the abolition of the monarchy and the House of Lords and the relinquishment of power to General Oliver Cromwell and the army. (http://www. americanrevolution. com, n. d. ) Under Cromwell's dictatorship, the size of the military establishment under the British king was limited.This had a negative effect on the colonies, where Cromwell's absolutism fueled distrust of standing armies and the employment of professional soldiers. (http://www. americanrevolution. com, n. d. ) To compensate for the lack of soldiers, the colonies resorted to citizen-soldiers. (http://www. americanrevolution. com, n. d. ) A law passed in 1777 required able young men (except for slaves) to render military service to the colonies. They were trained in the basics of war and law enforcement and were also considered potential recruits for short military offensives in the frontier.Land grants were often provided in exchange for able soldiering, turning the military into an attractive prospect for laborers with no property of their own and their sons. (http://www. americanrevolution. com, n. d. ) But the American Revolution left some problems unresolved, if not created new ones. The Americans remained divided on the topic of slavery (Brinkley150). Slavery was abolished in states where either slavery was minimal or was non-existent at all, such as in New England and Pennsylvania, respectively (Brinkley 150).Even the South experienced pressure to rectify or even abolish the custom. All southern states except South Carolina and Georgia banned further importation of slaves from other countries, while South Carolina also prohibited slave trade during the war (Brinkley 150). Virginia created a law calling for manumission (the freeing of slaves) (Brinkley 150). However, slavery still survived in all southern and border states. The American Revolution also did little to promote the rights of women.Although the war made it easier for women in some states to obtain divorces and allowed women in New Jersey to vote, they still remained inferior and dependent on men (Brinkley 147). They had no access to education and h ad no legal protection from abusive and tyrannical men (Brinkley 146). Married women had no property rights of their own, making it difficult for widows of revolutionaries to regain their dowries from their husbands' estates (Brinkley 147). Aside from the issues of slaver and the emancipation of women, the Americans had to deal with post-war economic depression as well.(http://www. historyplace. com, n. d. ) The hostilities left Americans with a host of economic problems, such as shortage of currency, high taxes, nagging creditors, farm foreclosures and bankruptcies. (http://www. historyplace. com, n. d. ) Increasing poverty at this period led to rebellion and violence. On August 31, 1786, to avoid the trial and imprisonment of debtors, former war captain Daniel Shays led an armed throng and stopped the Northampton Court from observing a hearing (Shays was already an impoverished farmer at the time of the revolt).Shays and his followers later instigated several related uprisings. Th e American Revolution served as a model for later revolutions in Europe and Latin America. It served as the primary influence in the French Revolution (1798-1799), the Haitian Revolution (1791-1804) and the South American wars of independence (Venezuela – 1811; Argentina – 1810 and Chile – 1810). But the most important lesson it taught was that while the oppressed can free themselves from a tyrant, they should ensure that they deserve the freedom that they won. Works Cited Brinkley, Alan.A Survey: American History. New York: McGraw-Hill Companies, 2007. â€Å"Essay on Declaration of Independence and American History. † n. d. Megaessays. com. 16 January 2007 . â€Å"Sugar Act. † n. d. Social Studies for Kids. 15 January 2008 . â€Å"A Summary of the 1765 Stamp Act. † n. d. Colonial Williamsburg. 15 January 2008 . â€Å"A New Nation: 1784 to 1790. † n. d. The History Place. 15 January 2008. â€Å"Three Branches of Government. † n . d. Utah Education Network. 15 January 2008 . â€Å"Early American Governments and the Confederation. † n. d. Grazian-Archive. com. 15 January 2008 . â€Å"The US Army and the Founding of the Republic. † n. d. AmericanRevolution. com 16 January 2008 .

Employment Relations Essay Example | Topics and Well Written Essays - 1500 words - 2

Employment Relations - Essay Example Workplaces have been using flexibility like outsourcing and casualisation which have a less direct relationship between employer and the worker. The employers prefer flexible labour policies as it allows them to adjust to match the changing demand patterns, thereby enabling the employers to exercise internal numerical flexibility. They are able to attain external numerical flexibility when they outsource particular functions. Employers benefit as they save on costs by engaging labor on just-in-time basis. Outsourcing helps to avoid capital investment and the funds can be used for other investments. By contracting out, the employers also gain as they are able to de-unionize the unionized workforce. Most importantly, through outsourcing, employers gain from the highly specialized skilled workforce that can be available. The employers may have to compromise on quality as the flexile workers have less experience and expertise. The flexible workers are less likely to receive training as t hey are not integrated into the human resource system of the organization. Co-ordination and delivery of services also pose problems in outsourcing out work. Employees benefit as it serves to provide temporary employment to many who do not want full-time employment and also serves a springboard for those who are looking for stable employment.

Writing Assignment - State of the Union Essay Example | Topics and Well Written Essays - 750 words

Writing Assignment - State of the Union - Essay Example Therefore, this is the work of the Senate but he points out that it has failed to do so. The President claims that he will use all his powers to make sure that the systems work as required and promises that this will happen by the end of the year. In his proposal, he tells the chairman of the House committee to prepare a bill that is aimed to measure those crossing the US border illegally. The bill targets to improve the equipment and the technology employed at the Southwest border. As a response to the proposed law, Sen. Ron Johnson (R., Wis.) a Republican, who also is the incoming House chair points out that; there was an anticipation of advancing the border legislation with the aim of providing additional fencing, surveillance, bettering visa tracking technology and enforcing the workforce related to this department. The enforcement should be done by making the use of e- verify mandatory, coming up with a system for employers to check the validity of their potential employees being in the USA soil. The senator points out that, the stated measures would be a vital and important component of any prospected immigration reform like the one stated by the president in his proposal. Again, the president points out that, including specific border targets for security improvement is vital in ensuring an evident progress on the run to reforming immigration practices in the US. The president also says that, there is the need to improve the U.S worker programs so as to address the rising demand for workers from outside the country. These workers come into USA country to fill both high and low skill positions that the Americans workers lack. In his proposal to the Congress, the president also addresses the issue of immigration. He points out that, several reforms should be employed so that the tax collection process in the USA is streamlined. The president talked about

Sky Essay Example | Topics and Well Written Essays - 2750 words

Sky - Essay Example Ltd, a Chinese car manufacturer that wishes to expand its business internationally with the help of mergers and acquisitions with existing company in host country. For the company, I suggest a business expansion in Mexico country through merger with Mastretta, a Mexican car manufacturer. This company established in 1987 and produced self-developed cars and sports cars with the help of experienced engineers and designers of Mexico. On the other hand, Chery is founded in 1997 and it produced passenger cars, minivans and SUVs (Chery International, 2010). On the basis of output, it is the ninth largest automaker in China. It exports around 25% of total production around the world. The company has various factories in different countries such as Iran, Malaysia, Indonesia, Middle East, Russia, Pakistan, Taiwan, Thailand and many more that produces Chery vehicles (Chery International, 2010). Now, the company wants to expand its business in Mexico. In this, various reasons to expand business in this country, factors that influence the transfer of business and marketing mix for Mexican market will be discussed. Along with this, environmental analysis of Mexico country will be done with the help of evidence and examples. Analysis In the overseas business expansion, companies has faced various issues regarding different political and economic conditions, cyber risks, corruption, different culture, labor laws, education system, infrastructure and ethics. In order to select a country or location for business expansion, various factors are considered such as commute patterns, infrastructure, land availability and labor availability (Russell and Cohn, 2012). According to these factors, US is best choice but in other countries, company can face issues of changes in government and laws, tax systems, labor cost and labor laws. Along with this, timeline, rights and preservation of workers, incentives, working hours organizational and culture management techniques are different in overseas business expansion. Reasoning Chery, a Chinese car manufacturer company wants to expand its business in Mexico. The company selects this country for business expansion because the automotive industry of Mexico is growing industry. It is attractive for automotive manufacturing companies due to proximity to the US and it is the world’s largest automotive market (Contreras, 2008). Along with this, various automobile companies from US, Japan and Europe shifted their plants in this country to get the benefits of strategic location, low labor cost and NAFTA (Moreno and Kellogg, 1996). The automotive industry in Mexico contributes 18% in manufacturing GDP and creates around 56,000 jobs (ProMexico, 2013). Apart from this, there are various reasons to select this country for business expansion such as: Free trade: This country has more free trade agreements as compared to other countries and USA. For example, Mexico has free trade agreements with EU that is helpful to save 1 0% tariff. Along with this, Central Mexico is the highest growth area for the production of vehicles and it is not only for US and Canadian market but also for global production (Russell and Cohn, 2012). Apart from this, due to suitable business conditions, various automakers announced $7.8 billion of investment in Mexico within two years (See: appendix 1). So, this country is good for the business expansion

Push-pin studios and its impact on graphic design in the 1960s Essay

Push-pin studios and its impact on graphic design in the 1960s - Essay Example In his comment, Chwast appreciates Milton Glaser for recognizing that a studio would generate greater long-lasting likelihoods for the people involved. By 1954, the three associates were able to start off a business with very low capital. They used their unemployment cheques for renting a flat on the 17th Street East of Manhattan. The rent for the now Push Pin company was less, and a pay phone met all their business operational requirements. Exhibit assignments for academic slide shows and provision for package plan proposals offered a reputable cash flow. Following salary payments to the secretary and the assistant, each individual member of the studio took with him $25 per week. They moved to a better location in New York 57th Street on the East in 1956, but this was the day that Sorel quit the studio, leaving Chwast and Glaser to carry on. The then approach undertaken by Push Pin took some time to evolve. Even though studio members used to work in unison on design projects, it was upon an individual to carry out editorial illustration. A communal impulse to extend the boundaries of recognized methods and to join illustration and design was the drive to rename and broaden the Almanack and come up with the Push Pin Graphic. As per the feedback and the outlook of the way the business was operating, this visually enthusiastic periodical led to a mix in the design community. This was not just an efficient way of showing off the talents of the studio, but also had a very big influence n the art and design direction of the late years of 1950s and the early sixties, particularly on the junction of design and illustration. A small but interesting graphic creation which attests to the influence of the Graphic was experienced when Glaser and Chwast put the entire art in one issue in cartons with rounded cameras. After some few w eeks,

Journal 4 Essay Example | Topics and Well Written Essays - 250 words - 1

Journal 4 - Essay Example Their experience showed that contrary to common sense, aggression, accidents and the stress of enforcing rules are all reduced and transformed when rules were discarded by the staff in a collaborative process. There were three non-profit site centers (63 students in a university campus, 42 children in a workplace setting, and 32 children in high school). All are in inclusive settings with resource teacher consultants for children with special needs. There was a lot of diversity in the three centers including speakers of English as a second language, newly arrived immigrants, children from a single parent family, etc. All centers were practicing the conventional way, which was rule-based. There was an abundance of Do’s and Don’ts, in other words, over-regulation, which was suffocating the children. They also found out that it was draining the teachers just policing and redirecting the children. Finally, they found out that there was a better way of doing these things. With the influence of the Reggio Emilia Approach in their series of workshops, they were able to question old concepts and approaches. They initiated new and innovative ways to make learning more meaningful and stress-free. The operative word was â€Å"collaboration†. With brilliant results emanating from the reduction of rules in a setting, it also led to explorations with the physical environment, such as redesigning the layout of the cots at naptime, enlarging the block area from 4 ft by 6 ft to 10 ft by 20 ft, thereby giving ample space to chidren with better results. They also started redecorating their environs with Monet prints, flowers and even the bathrooms to make for a calmer effect on the children. As a result, the rule-driven, clock-driven practice was changed into values-based, responsive pedagogy. Of course, there were some who were resistant to change. Eventually, they had to embrace the new innovation because it lessened

READING REFLECTION - DESIRING GOD by John Piper - TURABIAN FORMAT Essay

READING REFLECTION - DESIRING GOD by John Piper - TURABIAN FORMAT - Essay Example He supports his arguments by citing Judas Iscariot’s betrayal of Jesus Christ, which was a sin to fulfill God’s plan and will. Piper states that God’s pursuit of pleasure from us and our pursuit of pleasure from him are the same things.2 The main purpose of conversion is to select the few that will enter the Kingdom of heaven. Not all people who talk of God will enter the Kingdom, but only those who turn away from sin, repent and trust in God. From his book, Piper likens worship to a feast of Christian hedonism. He states that from biblical interpretations, worship includes outward acts including praying, preaching, cleansing, reciting, ordaining, lifting hands, bowing, and performing rites of eating.3 In addition, true worship must include inward feelings and thoughts that reflect on God’s worth and glory. Piper continues by stating that love is the overflow of joy in God. Love is reflected from outward acts and activities performed by people. God is love, and He loves a cheerful giver. Piper continues to state that what a person feels about money can either destroy or build one. What one does with his money forms a foundation that can build his happiness or ruin him forever. In marriage, husbands are told to love their wives because their wife’s body is theirs. They are required to do so just like Jesus died for the church. Christians are expected to continue with Paul’s missions of preaching the gospel. They are supposed to preach it in new regions and territories and to people who have not yet received it. In going out to missions, Christians are supposed to expect suffering, but put it in their hearts and minds that all their suffering is for Christ and with Christ. As such, they are not supposed to despair, but put in more efforts until they achieve their goals. The primary thesis of the book, which is Christian hedonism, relates to both private and public worship in many ways. This is mainly

The Navy Offers Better Job Benefits Than Civilian Jobs Essay Example for Free

The Navy Offers Better Job Benefits Than Civilian Jobs Essay Basic Thesis The Navy job gives more benefits than any civilian job. The Navy cares of its sailors. On enrolling, sailors will get an impressive array of benefits design to keep them healthy, comfortable and safe. The most distinguished part is that all of these previliges are above and beyond   Navy pay and grant. Health Benefits11 Two words — complete exposure. One other fringe benefit for on job Naval presonnels a is the complete healthcare exposure they get at all armed forces hospitals and dental benefits. If any one type of precise assistance were not obtainable, you would get a recommendation to where you require to go. This would also be included by Navy’s healthcareplan. Anytime there is any emergency or medical problem, visit neighboring medical benefit. Once a command has been reported to, the serviceman will be alloted a basic care physician, who can be a Navy doctor or a civilian physician. (Conway and Susan, 1990) Salary Benefits If the serviceman are searching for a occupation that offers him with much more than a only a salary, then the Navy is the place. Additionally to base pay, the Navy provides: Living lodgings or housing grant Free of cost dining assistances or food grant A uniform grant Complete healthcare benefits Additionally, Sailors at few duty stations are eligible for additional Cost of Living Grant (COLAs). When the serviceman add it all up,   pay in the Navy will be accumulate to much more than the similar pay in a civilian job where   basic requires aren’t already included. Job Guarantee The Navy offers excellent job guarantee. When the serviceman sign   bond with the Navy, it also signs one with the serviceman. The Navy assures to give the serviceman the training the serviceman require and put the serviceman in positions where the serviceman will be dared and can excel. The Navy assures to let the serviceman develop   management skills. And the more the serviceman give to the Navy, the more is returned by the Navy to the serviceman. (Conway and Susan, 1990) Employers will have strong incentives to hire the serviceman since the serviceman will have both excellent training and hands-on experience under   belt. Whilst in the Navy, the serviceman will learn both how to direct and how to implement the orders from seniors, allowing the serviceman to move into a range of positions. The character, sincerity and individual qualities developed whilst in the Navy are appealing to most employers. Family Benefits By enrolling the Navy family, the serviceman provide benefits for   family too. If the serviceman are married, with or without children, the serviceman can count on the Navy to care for the serviceman care for   family. First is the guarantee of a Navy job. Then there is the closeness of the Navy society — even if the serviceman are away from home, the Navy provides a strong support system for   family. And the quality of life in armed forces housing is exceptional. The Navy also provides the serviceman and   family housing and medical care. The serviceman can live on base or get a housing grant to live in an off-base house or flat of choice. Living on base offers perks same as residing in a gated society: guarantee, safety, cleanliness and a friendly, open environment. They are also constructed with the ease of the residents in mind. Wherever in the world the serviceman are stationed, the serviceman will find all the comforts of home: theaters, libraries, schools, day care and places of worship to say some. In short, living on a Navy base is no different from living in any civil society in America. Travel The Navy is a great way to explore the world, though there is frequently additional to see than the serviceman can get to. In the Navy, the serviceman get a chance to travel even when the serviceman’re not aboard ship. The Navy’s fantastic travel benefits begin with time off. Sailors get 30 days of paid leave annually. That’s a complete month throughout which the serviceman can relax, visit family — or travel to new places. It is easier to go places than the serviceman might imagine. Sailors can travel on armed forces flights around the world for free of cost on a standby, space–obtainable basis. If there is space on a flight going   way, the serviceman can get aboard. Additionally, as an active-duty member of the armed forces, the serviceman will often be qualified to reside in base lodging anywhere in the world. This includes lodging at any armed forces benefit, not only at the Navy’s, usually at a cost much lower than the serviceman would find at a hotel off base. Retirement When the serviceman decide to leave the Navy, the serviceman will continue getting assistance as a Navy expert. This can include the assistances of the Experts Administration in terms of finding job or schooling, no-money-down and low interest loans for new homebuyers, special hiring for government jobs, and receiving of Montgomery G. I. Bill money for school if the serviceman decide to contribute throughout enlistment. If the serviceman make the Navy   profession,   retirement benefits will be far greater. The serviceman will get generous retirement pay, and the serviceman will continue to get medical perviliges and on-base shopping benefits similar to those the serviceman enjoyed whilst on duty. Education The Navy emphasis a lot of importance on education. The Navy supports all Sailors to carry their education. To care for the serviceman, the Navy offers fund for college, means to pay off student credit debts, and also offers college classes on ships and bases. References Conway, Terry L. and Woodruff, Susan I. (1990) Perceived Quality of Life and Health-Related Correlates among Men Aboard Navy Ships; Armed forces Psychology. Volume: 2. Issue: 2. Pg 79.

Cystic Fibrosis: Molecular Mechanisms and Diagnosis

Cystic Fibrosis: Molecular Mechanisms and Diagnosis Cystic fibrosis is a membrane transport disorder which is commonly affected in the autosomal recessive disease of white populations. It is also identified at birth by a certain condition called meconium ileus which means intestinal obstruction. In the advance stages, clinically it has been diagnosed by sticky viscous secretion of the pancreas and lungs (Gelehrter, 1998). Many years of direct research has failed to recognise the specific gene which is involved in cystic fibrosis (CF), although there are some various indirect research done which has indicated that there appeared an abnormality in the transport of ions during the process of cell membrane development. A very common diagnosis has been used to recognise this disease which is high increase of chloride content in sweat. Children suffering from this disorder develop pancreatic insufficiency which is usually treated with enzyme supplementation, antibiotics and physical treatments which are used to reduce the chest infection. Earlier the survival average is about 25 years. (Gelehrter, 1990). But in a recent study, it has been said that the life expectancy for cystic fibrosis patients has increased over the last 40 years. It has been necessary to identify the respiratory viruses in Cf to make the clinical decision to proceed with the necessary treatment. (cited in Wat, 2008). It is said that one can calculate approximately the frequency of heterozygous carriers would be about 1 in 25 individuals. There are various research works done on cultured cells and animal models to further study on the basic defects of the disease and find a successive treatment. (Hodson, M.E., 1995). HISTORY: From centuries the study and research of Cystic fibrosis has been done. Earlier people started diagnosing this condition in the newborns due to the salty taste in their skin. The survival rate was so low as six months. But as years followed, during the 1930s, a scientist named Guido fanconi had described the symstoms as gastrointestinal symdrone but latter named it as cystic fibrosis. The research had advanced when the cystic fibrosis gene was discovered following the study of mendels law researched by Gregor Mendel. The genetic knowledge on this particular disease was made more improving which indirectly improved the survival ascepts of CF patients. By 1980s, a deeper understanding of human genetics were developed. In 1989, two researchers had isolated the damaged gene in causing CF which was the main cause in affecting the chloride channel function. These were the channels which were helping in the movement of water and salt in the cell walls. Further study on this is making it pos sible to understand and find a treatment for this genetic disease. In recent years, various study via Gene theraphy has been helping various researches to fix the damaged gene. If this particular gene is fixed, the possible prevention, treatment and cure of CF would become a (Giddings,2009) Basic molecular genetics of Cf: In the year 1985, several groups were experimenting on gene therapy by linkage analysis, a linkage was observed on the chromosome 7, which in turn proceeded with testing some of the markers on chromosome 7 where they found CF gene near to these markers (met and J3.11). Techniques like physical mapping showed that the distance between these markers was approximately 1.6 million bp, which is as large for approximately 50 genes. Various interesting research were made in which it was found that a vast majority of chromosomes carrying the Cystic fibrosis mutation were also carrying a particular alleles for XV-2c and KM-19 which was further named as allele for XV-2c and + allele for KM-19. This type of hapotype (-/+) showed approximately in 25% of normal chromosomes, whereas rest showed other different patterns. A term was defined for this type of disease gene associated with a allele with the nearby markers, which was named as Linkage Disequilibrim. This term was made used to understand that these CF mutated genes were being descended from a common ancester. (Gelehrter, 1998) In a recent research, a genetic analysis was conducted by carefully cloning of a 500,000 bp candidate which resulted in three possible genes from the specific region which was studied. In testing under northern blotting technique it was found that this specific gene was coding for a 1480- amino acid protein including 26 exons with a length of 250,000 bp of DNA and the mRNA transcript was found to be 6129 bp long. In further studying a cloned and sequenced cDNA was prepared using the sweat glands of a Cf patient, it was found that there was a difference in exon 10 from a normal sequenced gene. There was a deletion in the 3 -bp found which might have caused the deletion of a single amino acid (phenylalanine) at the specificresidue 508. (Gelehrter, 1990). This type of mutation is known as Delta F508 or F508. Patients with homologous delta F508 mutation will tend to suffer with severe symptons of this disease, causing a very heavy loss of chloride ion transport.This causes an improper balance in the sodium and chloride ion ratio, eventually secreting a thin, mucus secretion in the lung area which traps bacteria, this causes severe lung infection, resulting a high mortality rate in CF patients. CFTR gene: This gene was initially cloned in 1989 in which it was mapped to human chromosome 7q21, with more interest in this particular region, researches were able to indentify 2 more closely linked markers other than (labelled MET and D758) which were D75122 and D75340, those were 10 kb part. Using lambda genomic DNA libraries, 280 kb of DNA were sequenced which were used to make long range restriction maps. These were also probed with cDNA clones to isolate a total of 500 kb. This can be seen in the figure By using various approaches like screening zoo blots, northern blots and cDNA libraries the genomic DNA clone was isolated. Four different regions were isolated, out of that, only one proved to be CF gene which was 6.5 kb sequence in length. Eventually, it was concluded that the CF gene controls the CFTR (cystic fibrosis transmembrane regulator) which encodes chloride channels which were responsible for the water transport on the plasma membrane of the epithelial cells which were connected to the lung airways. This mutation was causing the problem. Structure of the CFTR gene: After sequencing the CFTR gene, further study was done on it. The sequenced coding region of this gene showed a polypeptide molecular mass of 168138 daltons. The best site seen in this predicted protein was that it showed two repeated motifs, which showed some similarities to the nucleotide-binding domains (NBD) which is present in the membrane bounded protein. These membrane consisted in them six hydrophobic regions which composed 234 amino acids. Hydrophilic domains: These 2 hydrophilic domains contains approximately 150 amino acids in which some phenylalanine residue has been deleted at the region of the first NBD which shares similar homologies with the proteins which binds with the nucleotide. These two motifs are connected by a highly charged cytoplasmic domains referred as R- domain or regulatory domains. This domains encodes 13 exons that help in the phosphorylationby protein kinase K and rest helps in binding sites by protein kinase C. These domains and nucleotide binding folds in the binding sites suggest that hydrolysis is involved in the transportation of CFTR gene. CFTR Promoter: It was found out that CFTR gene had a addition promoter region with a size of 3.5 kb, later on, it led that these promoters showed the characteristics of housekeeping gene along with tissue specific functions. There were five reasons that were focused to show that the CFTR gene had these charactertics which were as follows: There were no TATA box element within the first 500 basepairs of the transcription sites. The GC content in the promoter region was high. There were addition multiple minor transcription sites identified along with the major transcription sites. Couple of SP1 sites were also identified. There was a very low expression of the CFTR gene found in the epithelium layer. Another conclusion was made that the CFTR gene might control transcription regulation. (prin mg, tho) Phenotypic function of the diseased gene: To understand the phenotype of the disease, it has been confirmed that an individual suffering must have two copies of a mutated Cystic fibrosis transmembrane conductance regulator (CFTR) gene to be expressed. It has also been understood that the development of this disease in different individuals varies due to differential influence by environmental and genetic factors. This various different forms of other genes can affect the phenotypes of the mutated gene of this disease.   MUTATED GENE: As it been understood that the most common mutated gene found in most cystic fibrosis defective gene is the delta F508. A detailed study about this gene was done in which it was found that CFTR protein helps in encoding single amino acid at position 508 on the chromosome 7. As this mutation affects the CFTR to perform its work in the cell and prevents it from locating itself in the cell membrane. Usually it is seen that, a newly synthesized CFTR protein adds itself to the missing chemical group by folding itself into appropriate shape which are escorted by their specific molecular chaperons to the surface of the cell. Because of the presence of this mutated CFTR gene, the imperfect CFTR binds onto the cell membrane which has a defect while opening and closing during regulating the chloride ion flow within the cell membrane. There are different mutated genes, in which some do not this synthesis or any modification or integratation into the membrane of the cell. Sometimes, these mutated genes fail to even respond to the signals within the cell that are responsible for the opening and closing of chloride flow. In some cases, the CFTR protein enters the cell membrane and also responds to the cell membrane but there would show a problem when the channel opens and there is improper flow of chloride ion out of the cell. Different mutations vary with different patients, patients with absent or very low CFTR protein in its cell membrane would cause severe disease causing depleting pancreatic functions. There are patients which have delta F508 mutation on both CFTR gene copies, this causes very poor pancreatic function which would secret high amount of mucus causing varying degrees of infection in the lungs. Another CFTR mutation namely R117H also develops a partial functioning CFTR protein, this mutation pairs w ith the severe mutated gene delta F508 causing the CF disease severe but varying in lung disease. It has been seen that some men who have been detected with this particular mutated gene R117H shows only one symptom of CF that is being Infertile which is due to lack of vas deferens. Inheritence of the CF gene: Diagnosing cystic fibrosis In most cases, cystic fibrosis is diagnosed by screening tests, which are carried out very early in life. However, some babies, children and even young adults have some unexplained illness in future so they are diagnosed later. There are four main ways of diagnosing cystic fibrosis: newborn testing antenatal testing carrier testing sweat testing Newborn Screening: In newborn screening there are two tests the first one is blood test in which small amount of blood is taken from the babys heel and transferred onto the card and it is examined in the laboratory for CF and it is also test inherited conditions, such as sickle cell anaemia and phenylketonuria.. Another test is genetic test in which saliva sample taken from the cheek and check whether a newborn has faulty CFTR genes. Antenatal testing: This test is done during the womens pregnancy to know that fatus has CF or not. There are following Amniocentesis: in it inserts a needle through abdominal wall into the uterus and take amniotic fluid surrounds the baby and tested in the laboratory Chorionic villus sampling: In it needle passed through the stomach into the womb sometimes a fine tube passed through the vagina into the neck of the uterus as an alternative. And take chorionic tissue which is a tiny piece of the developing placenta and these chromosomes which are in the cells of the tissue are examined in the laboratory for CFTR genes are normal or not. Both tests have risk of complication and also chance for miscarriage so it is offered only those mothers who have high risk of having child with the CF. Carrier testing: People who have two CFTR genes one is normal and another is faulty are CF carriers. So carriers pass faulty CFTR genes on to their children. This is simple test which is uses mouthwash to make sure that person is a carrier of cystic fibrosis. Swishing the mouthwash to collect the cells. And these containing cells are checked for the faulty gene. Sweat test: If blood and genetic tests have positive sign for CF so for confirmation sweat test diagnosis using This test measure the amount of salt in sweat. For that in one treatment room small area of skin on an arm or leg tested. Rub this skin with sweat producing chemical and then produce gentle electrical current with help of electrode it gives warm feeling .collect sweat on a pad or paper for analze. High levels of salt confirm diagnosis of CF. (180,205) Immunoreactive Trypsinogn: This analysis is used after sweat test if little sweat measured in newborns. Blood samples are taken after 2-3 days of birth and examined for immunoreactive trypsinogen (IRT) which is the increased levels of pancreatic enzyme. If IRT level is high then also it is not strong indicator of CF. Because infants with intestinal malformations and condition as bowel obstruction also have high level of enzyme which is for function of impair pancreatic. Lung X-rays and function tests: In the tests measure the amount of air the lungs can hold and how fast a person can breathe out to show how lungs add oxygen and remove carbon dioxide from the blood with the help of chest X-ray which show lung scarring from recurrent inflammation.This test do not confirm a diagnosis of CF but help in evaluating the severity of an individuals lung damage. Sinus X-ray: This test give signs of sinusitis, which indicates an infection and inflammation of nasal cavities. The X-ray shows the underlying cause becomes important for sinusitis. By cause of sinusitis is showing allergies and poorly functioning immune system. DNA mutation analysis: For highly specific result we used this technique for CF to look for the presence of many mutations in the CFTR gene. In it DNA isolated and purified from the blood sample or from a smear inside the cheek and for detect disease genes and indentify mutation within a specific DNA sequenced used micro array technology Sputum cultures: For this test, take a sample of your sputum (spit) to see what bacteria are growing in it. If there are bacteria called mucoid Pseudomonas, then it is advanced CF that needs aggressive treatment. (Giddings, 2009) TREATMENT In early years, there were no proper complete cure for cystic fibrosis . This has changed in recent years due to various researches done to treat CF which have been improved drastically. The aim for the treatment of cystic fibrosis are to Prevent infection in lungs,Remove the thick and sticky mucus from lungs, Prevent blockages in intestines and to Provide adequate nutrition.(http://www.nhlbi.nihHYPERLINK http://www.nhlbi.nih.gov/.gov/) Treatment for lung problems: It is essential to begin the treatment by reducing the infection and removing the thick and sticky mucus from the lungs. This can be done by performing the following lung treatment methods. CHEST PHYSICAL THERAPHY (CPT): This theraphy is also called percussion. CPT include pounding the chest and back over and over with the hands and a device that reduce the mucus layer from the lungs. Breathing techniques are also helpful to remove mucus from lungs. This techniques involve forcing out of some short or deeper breaths and following with a relaxed breath. The major purpose of this therapy for CF is to increase clearance of mucus and control infection in the lung and also to provide adequate nutrition and prevent intestinal blockage. MEDICINES: This is the primary treatment for the cystic fibrosis. Using medicines it helps in treating lung infection, decreases the swelling ,reduces the mucus and also opens the airways. The following types are the antibiotics used for cystic fibrosis treatment: Oral antibiotics are use to treat the lung infection. Inhaled antibiotics are used to control the infection caused by the pseudomonas bacteria. Intravenous medicines are used for control the severe infection. Anti-inflammatory medicines used to reduce swelling in airways. Drugs or steroids such as azithromycin, ibuprofen, prednisone and pentoxifylline are used to reduce inflammation. For the treatment of bacterial infection various lung antibiotics such as nebcin, tobrex, ciprofloxin, myambutol, biaxin, azactam are used Exercise: Aerobic exercise can help to reduce and clear the mucus from the airways. Regular exercise also enables to cut back on the CPT. Intracytoplasmic sperm injection is used to provide fertility for men with cystic fibrosis LUNG TRANSPLANTATION: Lung transplantion is a effective therapeutic option for the cystic-fibrosis patient. The successfully lung transplanted patients are able to control diabetic problems easily as the patients exercise capacity improves and the respiratory infection reduces.(Madden, 1992). In lung transplant ,the infected lung is replaced with a healthy lung by surgery. If CF is very advanced then lung transplantion is a good option. It is a major operation and sometimes also leads to some serious complications Oxygen Therapy: If oxygen level is very low in the blood then oxygen therapy is very effective(http://cystic-fibrosis.emedtv.com). NUTRITIONAL TREATMENT: C.F causes many digestive problems such as slow growth, pain, intestinal gas and severe. Nutritional treatment can improve the growth, development and strength of patient. It involves a balanced diet with low fat and high protein which make strong the patient to resist aganist some infection (http://www.healthscout.com). It contain pancreatic enzymes to digest protein and fat and absorbance of various vitamins. Nutriational therapy also contain supplements of different vitamins. The other treatment for digestive problems is medications for the treatment of intestinal blockages (http://www.nhlbi.nih.gov/). GENE THERAPY: Gene therapy involve transfer of DNA for therapeutic purpose. For the treatment of cystic fibrosis two approaches have been used. In the first approach, adenovirus was used as a vector, it has the epithelial cell lining. In this approach, adenovirus type-2 late promoter drives the CFTR gene. In the second approach, positively charged liposomes was used which can bind negatively charged DNA on its surface. These initial experiments have been used to change the electrical conductance of the nasal membrane. By these approaches a little correction of conductance abnormalities is possible. In the recent studies aerosol inhalers is used to saturate the upper part of the respiratory system. The reversal of the path physiology is possible if the correct form of CFTR gene is expressed. At present, retroviral-mediated gene transfer system is used for gene transfer for gene therapy of CF. Adenovirus is a suitable vector for gene transfer to the airway because it uses humans as a permissive host and it has a natural tropism for the lung .Liposome-mediated DNA transfer system is also used for gene transfer in gene therapy. Liposome is positively charged interact with DNA which is negatively charged and form lipid-coated DNA complex Different positively charged liposomes used to transfer the CFTR including DOTAP, DMRIE and DOTMA-DOPE. Several new treatments are developed to treat the CF. In one case, the sodium-channel inhibitor amiloride is insert to the airways of the patients which inhibit sodium absorption. The other possible approach is to allow to bypass the CFTR chloride channel and regulate other chloride channel present in the membrane of airways. The most effective way to treat the CF is to insert a new and normal copy of CFTR gene into the airway of respiratory tract of CF patients. RECENT ADVANCES: In recent years, various research works have improved the way to diagnose and treat cystic fibrosis. In the year 2006, it was published in the Science daily that certain scientists from Stanford University, USA were able to find out the basic defect causing CF. In which they had concluded that the airway blockage caused in CF was not caused due excessive fluid being reabsorbed within the glands but due to lack of fluid secretion from cystic fibrosis glands. (http://www.sciencedaily.com/releases/2006/03/060318232035.htm) In another research work done in the year 2008, certain scientist from USA were able to discover that a particular protein called CFTR were either missing or not present in the lungs of the CF patients which helps in fighting various bacteria like Pseudomonas aeruginosa when inhaled. Further studies are conducted to find the treatment through these proteins. (http://www.sciencedaily.com/releases/2008/09/080910210525.htm). In 2010, A team led by Professor Justin Hanes from John Hopkins university had researched on a mucus penetrating biodegradable nanoparticles which would help in delivery wide range of therapeutic molecules from small to various size of macromolecules to reduce the infection of lungs of the CF patients. In another research study done this year 2010, a team of researches were able to find out that a certain calcium- activated chloride channel were able to enable CF mucous cells to secrete normally which is required in the CFTR channel. So, it was concluded that drugs should be produces to enchance the ability of the calcium response which helps in activating the calcium activated chloride channels which are secreted in the CF cells. (http://www.sciencedaily.com/releases/2010/09/100917151848.htm)

Preformulation Testing for Chemical Properties of Drug

Preformulation Testing for Chemical Properties of Drug PREFORMULATION STUDIES Preformulation testing involved investigation of physical and chemical properties of a drug substance alone and when combined with excipients. It was the first step in the rational development of dosage forms. These studies are categorised as under: 1. API characterization 2. Drug-Excipient Compatibility study API Characterization Organoleptic Evaluation These are preliminary characteristics of any substance which is useful in identification of specific material. Following physical properties of API were studied. a) Colour b) Odour Table no. : Characterization of API Test Observation Colour White Odour Odourless Particle size distribution Sieve analysis: The sieve analysis main concept is to know the different drug particles size in the sample. The standard sieves with larger pore size i.e., with less sieve number on the top position are placed one over the other and followed by sieves of decreasing pore size i.e., with larger sieve number towards the bottom. Procedure: Clean and dried sieves #40,#60,#80,#100,#120 and bottom meshes were collected Individual weight of each sieve was noted. These sieves were arranged in ascending order. Weighed quantity of API was placed in #40 meshes. Sieve shaker was set for 5 min at amplitude of 60. Remove the setup from sieve shaker after 5minutes. Each mesh was weighed individually and Calculate % retained in each size of mesh with following formula: % retained = Final weight – initial weight x 100 Total weight taken Table no. : Particle size distribution of API Sieve number Percentage of sample retained (%) Cumulative percentage of sample retained (%) 40 3.0 3.0 60 19.2 22.2 80 26.3 48.5 100 24.2 72.7 140 8.1 80.8 200 19.2 100.0 pH-Solubility Profile: The solubility studies for the drug were carried out using the orbital shaker. Solubility of the drug across different buffers was studied. The pH ranged from 1.2 to 6.8 (1.2 , 4.5, 6.8, and water). All the buffers were prepared according to USP 34 NF 29, 2011. Excess drug was added to 100 ml of water in stoppered conical flasks and were agitated continuously in a orbital shaker for 24 hrs at 200 rpm and room temperature (25Â ° C), till saturation was observed. Then, the samples were filtered using 0.45 Â µ Nylon (47 mm) syringe filters. Now the filtered samples were analyzed using UV spectrophotometer Table No.6.3 below describes the procedure of buffers preparation. Table 6.5 preparation of buffers Buffer Procedure PH 1.2 buffer 8.5 ml of Conc. HCL was added to 1000 mL volumetric flask. Then it was diluted and made up to volume with water PH 4.5 phosphate buffer 13.61 gm of KH2PO4 was added to 1000 mlvolumetric flask. Then it was made up to volumewith water PH 6.8 phosphate buffer 250 mL of 0.2 M monobasic potassium phosphate solution was taken in a 1000 mL volumetric flask. Then 112 mL 0.2M Sodium hydroxide solution was added to it and water was added to make up to the volume Table7.3 Solubility of API in buffers of different pHs PH Solubility(mg/ml) 1.2 42.36 4.5 44.96 6.8 0.80 Water 0.674 Fig 7.1 pH Solubility curve of API Drug excipient compatibility study There is always possibility of Drug excipient interaction in any formulation due to their intimate contact. It is also necessary to determine any possible interaction between excipients used in the formulation. This will also indicate success of stability studies. Preliminary studies: Method: Physical observation Condition: 40 Â ±2 o C and 75 Â ± 5% RH Procedure: Drug was mixed with excipients in 1: 1 ratios as indicated in the Table 6.6 These mixtures were kept in a 5ml glass vials and packed properly. In dry close method glass vials are closed with rubber stoppers These vials are exposed to 25ËÅ ¡C /60 % RH 40ËÅ ¡C /75 % RH. Blend (1gm) was prepared and filled in vials. Observations for physical appearance were made at the end 4 weeks. S.No EXCIPIENTS DRUG: EXCIPIENT RATIO 1 Polyethyleneoxide 1:1 2 HPMCK100M 1:1 3 MCC 1:1 4 Cellulose acetate 1:1 5 Sodiumchloride 1:1 6 Citric acid 1:1 7 Sodium lauryl sulphate 1:1 8 Magnesium stearate 1:1 9 Talc 1:1 Table 7.4 Results of Drug-Excipient compatibility at 25oC/60% RH S.no: Excipent Colour change Lumps Caking O C O C O C 1 Polyethylene oxide X X X X X X 2 HPMC X X X X X X 3 MCC X X X X X X 4 Cellulose acetate X X X X X X 5 Sodium chloride X X Lumps observed X X X 6 Citric acid X X Lumps observed X X X 7 Sodium lauryl sulphate X X Lumps observed X X X 7 Magnesium stearate X X X X X X 8 Talc X X X X X X Note: x – indicates no change, O- open condition ,C- close condition Table 7.5 Results of Drug-Excipient compatibility at 40oC / 75% RH S.no: Excipient Colour change Lumps Caking O C O C O C 1 Poly ethylene oxide X X X X X X 2 HPMC X X X X X X 3 MCC X X X X X X 4 Cellulose acetate X X X X X X 5 Sodium chloride X X X X Caking observed X 6 Citric acid X X X X Caking Observed X 7 Sodium lauryl sulphate X X X X Caking observed X 8 Magnesium stearate X X X X X X 9 Talc X X X X X X FTIR Study FTIR study: FTIR studies were carried out for pure drug alone and blend of drug excepients. The FTIR spectroscopy (BRUKER Optics FTIR spectrophotometer) is employed as analytical tool to check the drug-excepients interaction, using the KBr disc method. The FTIR spectra were scanned and recorded between 400 and 4000 cm-1 Method: Nearly to a fine alkali halide (example KBr) powder of 200 to 250 mg 0.1 to 1.0 % sample is mixed well. Later it is pulverized and in a pellet-forming die it is placed. Around an 8 tons force under a vacuum of several mm Hg is applied to form transparent pellets. FTIR spectroscopy of pure drug of Famotidine S.no Type of vibration Actual frequency (cm-1) Observed frequency (cm-1) Confirmation Table no. : Interpretation of FTIR spectra of pure famotidine FTIR spectroscopy of drug and excipient blends Table 7.6 Peaks of FTIR study Peaks ( cm –1) Functional groups 3506.13 –OH 3377.41-3400.95 –NH2 3238.03 -NH 1445.38- 1639.22 C=N 689.10 -606.6 C-S 1320.81 S(=O) 2 asymmetric stretching 1147.17 S(=O) 2 symmetric stretching Table no. : Interpretation of FTIR spectra of pure famotidine S.no Type of vibration Actual frequency (cm-1) Observed frequency (cm-1) Confirmation ANALYTICAL METHOD ESTIMATION OF FAMOTIDINE: A solution of Famotidine was prepared in 0.1 N HCl and Phosphate buffer pH 4.5and 6.8 UV spectrum was taken using Perkin Elmer UV/Vis double beam spectrophotometer.The UV maxima of Famotidine was found to be 265 nm in both 0.1N HCl pH 4.5. In pH 6.8 it was found to be 268 nm Preparation of standard curve of famotidine in 0.1N HCL pH 4.5 phosphate buffer: 100 mg Famotidine each was dissolved in 0.1 N HCl and pH 4.5 buffer and volume is made up to 100 with respective buffer. 10 mL of stock solution (1mg/ml) was further diluted upto 100 ml with respective buffer to obtained solution of 100 Â µg/mL.Now from stock 2 further dilutions were done with respective buffer to obtain solutions of 2, 5, 10, 15, 20 and 25 Â µg/ml Absorbance of each solution was measured at 265 nm using Perkin Elmer UV/Vis double beam Spectrophotometer. Preparation of standard curve in ph 6.8 phosphate buffer: 10 mg Famotidine each was dissolved in pH 6.8 phosphate buffer and volume is made up to 100 ml to obtain solution of 100 Â µg/ml. Now from this stock solution further dilutions were done with PH 6.8 to obtain solutions of 10 , 20 , 30 and 40 Â µg/ml Absorbance of each solution was measured at 268 nm using Perkin Elmer UV/Vis double beam Spectrophotometer. The experiment was performed in triplicate and based on average absorbance; the equation for the best line was generated. The results of standard curve prepared in pH 1.2, 4.5 6.8 were shown below Table 7.7 Standard curve of API in PH 1.2 , 4.5 6.8 buffers Concentration Absorbance in pH 1.2 Absorbance in pH 4.5 Absorbance in pH 6.8 2 0.085 0.082 4 0.141 0.148 5 0.189 0.186 10 0.333 0.341 0.251 15 0.510 0.497 20 0.701 0.651 0.467 25 0.852 0.806 30 0.746 40 0.989 FIG 7.4 standard curve at PH 1.2 Buffer Fig 7.5 standard curve at PH 4.5 Buffer Fig 7.6 standard curve at PH 6.8 Buffer Calculation of initial dose and maintenance dose for the design of elementary osmotic pump of famotidine for 12 hours: There are no sustained release formulations for famotidine in the market, hence the total dose (DT) consisting of initial (DI) and maintenance doses (DM) for formulating the famotidine sustained release was calculated as per Robinson and Eriksen equation with a zero order release principle36 . In this profile the rate of delivery is independent of the amount of drug remaining in the dosage form and constant over time as shown by the Eq. 6.1 Drug availability rate k0 = Rate in = Rate out Eq. 6.1 Where, k0 is the zero order rate constant for drug release (amount per time). DI is required to give initial rapid release of drug so as to attain the minimum therapeutic level immediately after dosing. Inital dose (DI) = CSSAVG Vd Eq. 6.2 F Where, C ssavg is the average steady state plasma level, V d is the volume of distribution and F is the fraction of dose absorbed. k0 = DIKel Eq. 6.3 Where, Kel is overall first order drug elimination rate constant (per hour). Hence k 0 should be equal to the elimination rate constant so as to maintain the steady state condition. In general the total dose required (D T) is the sum of maintenance dose (DM) and the initial dose (DI) DT = D I + D M Eq. 6.4 In practice, D M (mg) is released over a period of time and is equal to the product of H (the number of hours for which sustained action is desired after initial dose) and the zero order rate constant, k0 (mg/hr). Therefore the Eq. 6.4 can be expressed as DT = D I + k0H Eq. 6.5 Ideally the maintenance dose (DM) is released after DI has produced a minimum therapeutic blood level of the drug. However due to the limits of formulations, drug release even starts from DM also from the beginning i.e. at t=0, thus increasing the initial drug level in the blood. Hence it is necessary to reduce the initial dose of the drug to account for the excess release for drug from DM by using a correction factor, k0tp. This correction factor is the amount of drug provided by DM during the period from t=0 to the time of the peak drug level, tp. The corrected initial dose (DI*) becomes DI-(k0tp). Then the total dose is DT = DI* + k0H = (D I k0tp) + k0H Eq. 6.6 Pharmacokinetic parameters of famotidine: Elimination half life (t1/2) of famotidine is 3 hrs (average of 2.5 to 3.5 hrs), the time to reach peak plasma (t p) is 3 hrs and Vd = 80.5 L and F = 0.4 54,55 . From the literature of the PEPCID (innovator product of famotidine in USA) label and pharmacological review information 49,, it was found that the plasma levels after multiple doses are similar to those after single doses indicating the C max is similar to Cssavg , therefore Cmax of 0.07 mg/L was taken as C ssavg . Calculation of D I and DM: The initial dose (DI), corrected initial dose (DI*), maintenance dose (DM) and total dose (DT) were calculated according to calculations described above. Calculation of elimination rate constant: Elimination rate constant (K el ) = 0.693/t 1/2 = 0.693/3 = 0.231 hr -1 Calculation of initial dose: Inital dose (DI) = CSSAVG Vd Eq. 6.2 F = (0.07 X 80.5)/0.4 = 14.0875 mg Calculation of desired input rate (k 0): Desired input rate from maintenance dose (k 0) = DIKel = 14.0875 X 0.231 = 3.25 mg/hr Calculation of maintenance dose: Maintenance dose (DM) = k0H (Since, H = the number of hours for which sustained action is desired after initial dose = (12-1) = 11 hrs) = 3.25 X 11 = 35.796 mg Calculation of corrected initial dose DI*: DI* = DI – (k0tp) = 14.087 – (3.25 X 3 ) = 4.93 mg Calculation of total dose: Total dose (D T) = D I* + D M = 4.93 + 35.796 = 40.726 mg From the above calculations the total dose obtained for sustained release of famotidine for 12 hrs is 40.726 mg. The total dose was rounded off to 40mg for the convenience. Initially the dosage form should release the total initial dose (i.e. 4.93 mg ~ 5.0 of drug, means 11% of total 50 mg dose) in the first 1 hr followed by maintenance dose (i.e. 40-5=35 mg of drug) for up to 12 hrs there after at a release rate of 3.25 mg/hr (i.e. 8.125% of total 40 mg dose). Based on these assumptions the theoretical release profile was predicted and shown Table 6.7 Predicted theoretical release profile Time (hrs) % CDD 1 11.4 2 19.425 3 27.45 4 35.475 5 43.5 6 51.525 7 59.55 8 67.575 10 83.625 12 99.675 JNTUA-OTRI, Ananthapuramu 1

Industrial Revolution and Absolutism :: essays research papers

Section I, Question 2   Ã‚  Ã‚  Ã‚  Ã‚  In the early 17th century â€Å"absolutism† was not only thought of in the theological sense it was also a political catch word all through out Europe. England had a few rulers attempt to create an absolute monarchy. James I and Charles I both tried to have complete rule over the country without consulting Parliament. Parliament, which had a large portion of control, prevented these two rulers from successfully hindering their power. The citizens of England were very use to the combined rule of the king and Parliament. So they were not very eager or willing to release all the power to a single person. In Parliament an official could be changed if need be, and no one person could in charge of decision making. This is one of the main benefits to having a Parliamentary type of government. Toward the middle of the 17th century troubles between Charles I and Parliament sparked England’s civil war. This in turn created problems for future rulers with aspir ations about ruling without Parliament. England’s civil war was basically the death of royal absolutism; eventually Parliaments power grew to the point that it became the head body of government in England.   Ã‚  Ã‚  Ã‚  Ã‚  Royal absolutism failed horribly in England, this however was not the case in France. France did not have a power similar to Parliament to try and compete against the monarch for control. The citizens of France were also more willing to accept a single head of government. Most felt that having this strong leader would help protect them and keep the peace within their country.   Ã‚  Ã‚  Ã‚  Ã‚  So in conclusion it is clear to see that both systems of government have benefits and drawbacks. Parliament can help a country make better well rounded decisions and also keep a corrupt ruler in check. Absolutism, with the right leader, can help citizens feel more secure give the country a strong image. So in the end it comes down to what the people want and feel comfortable with. Section II, Question 3   Ã‚  Ã‚  Ã‚  Ã‚  The Industrial Revolution in its simplest form was the creation and use of power driven machinery in manufacturing. It began very subtly. There was a growing demand for agriculture and textiles and the current machinery was unable to keep up. One of the first advances in machinery was the use of water power. Mill owners created machines that could use the power of a flowing stream to enhance the speed of their textile machines.

Omnipotence And St. Thomas Aquinas :: essays research papers

Omnipotence and St. Thomas Aquinas Omnipotence literally means the ability to do all things, or to have absolute power. This quality seems to be generally accepted as an intrinsic characteristic of the Judaeo-Christian god, as it says in Luke I. 37, "...there is nothing that God cannot do.". Certain objections can be raised to attributing this characteristic to god however, in-so-far as this characteristic seems to conflict with other accepted attributes of god. In The Summa Theologica St. Thomas Aquinas addresses some of these objections, the most telling of which can be restated as: (I) To sin is an action, however god is unable to sin. Therefore god cannot be omnipotent. (ii) The greatest act possible of god is his practice of "sparing and having mercy". There are actions judged to be much greater however, such as creating a world. Therefore god is not omnipotent. (iii) If god is omnipotent, then everything is possible and nothing is impossible. If this is true however, things which are necessary (things which cannot possibly not exist) are no longer so. This is impossible - therefore god cannot be omnipotent. Aquinas begins his rebuttals by defining what is encompassed by the characteristic of divine omnipotence. He explains that god is able to all things which are "possible absolutely", which he defines as all things which can be logically expressed without the predicate being in conflict with the subject - i.e. god is capable of all things which do not involve a contradiction in terms. This does not imply any defect in the power of god, Aquinas goes on to say, because impossible things by definition have "no aspect of possibility", moreover, it is absurd to expect divine omnipotence to encompass the logically impossible. (I) Aquinas answers the first objection as follows. He explains that "...to sin is to fall short of perfect action; hence to be able to sin is to be able to fall short in action..." which he attests is contrary to the meaning of divine omnipotence. (ii) In answering the second objection Aquinas points out, "It is not

Continuity and Change over Time in Classical Civilizations

After the fall of the classical civilizations from 100 to 600 CE the world experienced many changes. China’s fall was not as drastic as Rome’s, but it was still worse than India’s. The collapse of the Han dynasty caused China to go into three centuries of unrest until the Sui and Tang dynasties came to the rescue. China had more continuities than changes after its fall, unlike the other classical civilizations.China went from a politically centralized civilization with a developed hierarchy with mutual respect of the upper and lower classes that followed Confucian ways of obedience and deference to the syncretism of Buddhism and Daoism during 100 to 600 CE because of nomadic invasions, corrupt bureaucracies, and religious fluctuations. However, bureaucracies and Confucianism remained. China’s collapse began because of outside nomadic invasions by the Huns. However, after the three centuries of unrest, the nomads simply tried to assimilate into Chinese trad itions after realizing they did not have anything better to offer.During the centuries of chaos, approximately one-half of the population was killed by epidemics. Confucianism, a large imprint of the ways of life in China, became intellectually less active. The bureaucracies became corrupt, which allowed Buddhism to expand to China and threaten its unity. After the bureaucracies corrupted, local landlords picked up power in local neighborhoods. This caused more taxes to the already heavily taxed peasants, causing further social unrest. During this time, Daoism’s appeal increased because of its healing practices and magic.A Daoist movement led by the Yellow Turbans (who promised a golden age) attacked the weak government; however, this failed and simply furthered the downward spiral of classical China. After three centuries of unrest in China, the Sui and T’ang dynasties stepped in. The T’ang dynasty is responsible for the glorious periods of China. This dynasty restored peace to China and revived much of its old ways. Because of the T’ang dynasty, China had returned to its Confucian ways as well as bureaucratic. Because of these dynasties, the bureaucratic system became more elaborate.Even though the bureaucracy declined during the pandemonium, it never did disappear. The structures of classical China were simply too strong to be completely overturned. Despite the continuities, China did exhibit changes after its political and social upheaval. Buddhism had become a major religion in the world because of the expansion eastward during classical China’s demise. Some Buddhist beliefs were syncretized into Confucian China. Despite the mark from the minor Buddhist presence, the chaos did not leave any permanent disruption like in Rome. China merely had to recover from a major setback, rather than reinvent an entire civilization.